The Antinociceptive Responses of MTDZ to Paclitaxel-Induced Peripheral Neuropathy and Acute Nociception in Mice: Behavioral, Pharmacological, and Biochemical Approaches.

The efficacy of 5-((4-methoxyphenyl)thio)benzo[c][1,2,5] thiodiazole (MTDZ) in mitigating paclitaxel (PTX)-induced peripheral neuropathy was investigated in male and female Swiss mice. The study examined the effects of MTDZ on various pathways, including transient receptor potential cation channel subfamily V member 1 (TRPV1), glutamatergic, nitrergic, guanylate cyclase (cGMP), serotonergic, and opioidergic. Mice received intraperitoneal PTX (2 mg/kg) or vehicle on days 1, 2, and 3, followed by oral MTDZ (1 mg/kg) or vehicle from days 3 to 14. Mechanical and thermal sensitivities were assessed using Von Frey and hot plate tests on days 8, 11, and 14. The open field test evaluated locomotion and exploration on day 12. On day 15, nitrite and nitrate (NOx) levels and Ca2+-ATPase activity in the cerebral cortex and spinal cord were measured after euthanizing the animals. MTDZ administration reversed the heightened mechanical and thermal sensitivities induced by PTX in male and female mice without affecting locomotion or exploration. MTDZ also modulated multiple pathways, including glutamatergic, NO/L-arginine/cGMP, serotonergic (5-HT1A/1B), opioid, and TRPV1 pathways. Additionally, MTDZ reduced NOx levels and modulated Ca2+-ATPase activity. In conclusion, MTDZ effectively alleviated PTX-induced peripheral neuropathy and demonstrated multi-targeted modulation of pain-related pathways. Its ability to modulate multiple pathways, reduce NOx levels, and modulate Ca2+-ATPase activity makes it a potential pharmacological candidate for peripheral neuropathy, acute nociceptive, and inflammatory conditions. Further research is needed to explore its therapeutic potential in these areas.

Physicochemical composition, fatty acid profile and sensory attributes of meat (longissimus lumborum muscle) from Nellore and Nellore-cross bulls.

This study aimed to compare the physicochemical characteristics, fatty acid composition, and sensory attributes of the meat from three genetic groups: Nellore (Nell), ½ Nellore × ½ Angus (NeAn), and » Nellore × » Angus × ½ Senepol (NASe). Longissimus lumborum muscle from 30 slaughtered bulls with a body weight of 549 ± 32.5 kg was used. The water holding capacity was greater for the Nell and NeAn groups than for the NASe group. Meat samples from the NASe group exhibited a higher L* index than those from the NeAn group and lower a* and b* color indexes than those from the Nell group. The meat fatty acid profiles showed that the Nell group had higher concentrations of 12:0, 14:0, 18:1 t11, 14:1 c9, 16:1 c9, 18:1 c9, 18:1 c11, 18:2 c9, t11 (conjugated linoleic acid (CLA)), and 20:3 n-6 polyunsaturated fatty acid (PUFA) than the NeAn and NASe groups. The total saturated (ΣSFA), unsaturated (ΣUFA), and monounsaturated (ΣMUFA) fatty acid concentrations were higher and the ΣPUFA:ΣSFA ratio was lower in the Nell group than in the NeAn group. The Δ9-desaturase C16 activity was significantly higher in the Nell and NASe groups than in the NeAn group. The atherogenicity index (AI) tended to be lower in the crossbreeds than in the Nell breed. The NASe group presented meat with better tenderness, juiciness, and overall acceptance than the Nell and NeAn groups and was therefore the best genetic group for beef production of the tested groups.

Conhecimentos e práticas de enfermeiros perante a assistencia às vítimas de violência em unidades de pronto atendimento em Belém-PA / Knowledge and practices of nurses regarding the care of victims of violence in emergency care units in Belém-PA

Objetivo: Identificar conhecimentos e práticas de enfermeiros perante a assistencia às vítimas de violência em Unidades de Pronto Atendimento em Belém-PA. Método: trata-se de um estudo qualitativo, descritivo, realizado em uma unidade de pronto atendimento. Coletaram-se os dados mediante entrevistas semiestruturadas por meio de um roteiro, analisando-os a partir da técnica de Análise de Conteúdo. Resultados: 1) Conhecimento de enfermeiros sobre sinais clínicos da violência; 2) Tipo de violência mais comum sob a ótica dos Enfermeiros; 3) Assistência de Enfermagem e o acolhimento frente às vítimas de violência; 4) Capacitação profissional para o manejo de enfermagem perante as vítimas de violência e 5) Percepções sobre fluxo e encaminhamentos. Conclusão: identificaram-se diversos desafios, tais como a identificação da vítima de violência, a qualidade da assistência, a falta de capacitação dos profissionais e o desconhecimento do fluxo do atendimento.(AU)

Objective: to identify nurses' knowledge and practices regarding the care of victims of violence in Emergency Care Units in Belém-PA. Method: this is a qualitative, descriptive study carried out in an emergency care unit. Data were collected through semi-structured interviews using a script, and analyzed using the Content Analysis technique. Results: 1) Nurses' knowledge about clinical signs of violence; 2) Most common type of violence from the perspective of nurses; 3) Nursing care and welcoming of victims of violence; 4) Professional training for nursing management of victims of violence and 5) Perceptions about flow and referrals. Conclusion: several challenges were identified, such as the identification of the victim of violence, the quality of assistance, the lack of training of professionals and the lack of knowledge about the flow of care.(AU)

Objetivo: Identificar los conocimientos y prácticas de las enfermeras sobre la atención a las víctimas de violencia en las Unidades de Atención de Emergencia de Belém-PA. Método: se trata de un estudio cualitativo, descriptivo, realizado en una unidad de urgencias. Los datos fueron recolectados a través de entrevistas semiestructuradas utilizando un guion, analizándolos mediante la técnica de Análisis de Contenido. Resultados: 1) Conocimiento de enfermeros sobre signos clínicos de violencia; 2) El tipo de violencia más común desde la perspectiva de los enfermeros; 3) Asistencia de enfermería y acogida a víctimas de violencia; 4) Formación profesional para la gestión de enfermería ante a las víctimas de violencia y 5) Percepciones sobre el flujo y derivaciones. Conclusión: se identificaron varios desafíos, como la identificación de la víctima de violencia, la calidad de la atención, la falta de formación de los profesionales y el desconocimiento sobre el flujo de atención.(AU)

Perfil sociodemográfico e clínico de pacientes com doenças cardiovasculares em um hospital geral / Perfil sociodemográfico y clínico de pacientes con trastornos cardiovasculares en un hospital general / Sociodemographic and clinical profile of patients with cardiovascular disorders in a general hospital

Objetivo: traçar o perfil sociodemográfico e clínico de pacientes com doenças cardiovasculares. Método: estudo observacional, descritivo, com amostra por conveniência de 50 pacientes com doenças cardiovascular, internados nos serviços de cardiologia e neurologia de hospital de Curitiba, Paraná. Os dados foram coletados por meio de instrumento estruturado de junho de 2018 a janeiro de 2019 e analisado por estatística descritiva. Resultados: verificou-se que 68% dos participantes eram homens, 84% com idade entre 51 e 60 anos, 58% brancos, 78% procedentes de Curitiba e região, 52% com baixa escolaridade. Observou-se que 58% não praticavam atividade física, 52% eram tabagistas; 40% afirmaram ingerir bebida alcoólica, 58% com renda familiar de até um salário mínimo. Dos participantes 58% tinham antecedentes familiares de alterações cardiovasculares, 84% eram hipertensos, 78% faziam uso de polifarmácia. Conclusão: o perfil dos pacientes com doenças cardiovasculares está caracterizado pela falta de hábitos saudáveis dos participantes, hipertensão e fragilidade social.(AU)

Objective: to delineate the sociodemographic and clinical profile of patients with cardiovascular disorders. Method: observational, descriptive study with 50 patients with cardiovascular diseases, admitted to the cardiology and neurology services of hospital, in Curitiba, Paraná, Brazil. Data were collected with structured instrument from June 2018 to January 2019 and analyzed using descriptive statistics. Results: it was found that 68% of the participants were men, 84% aged 51 to 60 years, 58% white, 78% from local region, 52% with low education. It was observed that 58% did not practice physical activity, 52% were smokers; 40% said they drink alcohol, 58% reported having a family income of up to one minimum wage. Of the participants, 58% had a family history of cardiovascular disorders, 84% were hypertensive, 78% used polypharmacy. Conclusion: the profile of patients with cardiovascular disorders is characterized by the participants' lack of healthy habits, hypertension and social fragility.(AU)

Objetivo: delinear el perfil sociodemográfico y clínico de pacientes con trastornos cardiovasculares. Método: estudio observacional, descriptivo con 50 pacientes con trastornos cardiovasculares, ingresados en los servicios de cardiología y neurología de un hospital en Curitiba, Paraná, Brasil. Los datos se recopilaron con instrumento estructurado desde junio de 2018 hasta enero de 2019 y se analizaron mediante estadísticas descriptiva. Resultados: 68% de los participantes eran hombres, 84% de edades entre 51 y 60 años, 58% blancos, 78% de la región local, 52% con baja educación. El 58% no practicaba actividad física, el 52% eran fumadores; el 40% bebían alcohol, el 58% informó tener renta familiar de hasta un salario mínimo. De los participantes, 58% tenían antecedentes familiares de alteraciones cardiovasculares, 84% eran hipertensos, 78% usaban polifarmacia. Conclusión: el perfil de los pacientes con enfermedades cardiovasculares se caracteriza por la falta de hábitos saludables de los participantes, hipertensión y fragilidad social.(AU)

Effect of Air-Particle-Abrasion Protocols on Surface Roughness and Early Biofilm Formation of Zirconia.

PURPOSE: The air-particle-abrasion on zirconia in the gingival area of connectors and pontics in fixed partial dentures appears to increase fracture resistance. This study evaluated 'in situ' biofilm formation on the zirconia surface after different air-particle-abrasion protocols. MATERIALS AND METHODS: Ninety sintered blocks (5 × 5 × 2 mm) of yttrium partially stabilised zirconia (Y-TZP) were obtained and randomised among nine groups according to the factors 'type of particle' (Alumina 50 and 110 µm; Cojet and Rocatec) and 'pressure' (2.5 and 3.5 bar) used for sandblasting for 10 s. The surface roughness (Ra/Rz) was measured before and after sandblasting. For the in-situ analyses, custom-made removable intraoral devices n = 10 with one sample of each group attached to the buccal area were used by volunteers for 8 h at night. The specimens were analysed under confocal microscopy to quantify both biovolume and thickness of the initial biofilm formed. One-way analysis of variance (ANOVA) and Dunnett's tests were performed (5%). RESULTS: The roughness values ranged from 0.05 to 0.39 µm for Ra and from 0.35 to 2.11 µm for Rz, p = 0.00. Mean biofilm thickness ranged from 0.06 and 0.54 µm (p = 0.005), while the biovolume values were between 0.02 and 0.61 µm3/µm2 (p = 0.002). Values statistically significant for biofilm thickness and biovolume were found in groups sandblasted with Rocatec using 3.5 bar. CONCLUSION: In order to increase the fracture resistance of zirconia fixed partial dentures (FPDs), the air particle abrasion of zirconia with SiO2 (110 µm/3.5 bar), in the gingival area of connectors and pontics, should be avoided.

Prematuro alimentado com leite humano versus leite humano acrescido de FM85® / Prematuro alimentado con leche humana versus leche humana suplementada con FM85® / Premature infants fed with human milk versus human milk enhanced with FM85®

Resumo Objetivo Comparar o crescimento de recém-nascidos prematuros de muito baixo peso internados na Unidade de Terapia Intensiva Neonatal, alimentados com LHP e LHP acrescido de suplemento comercial. Métodos Trata-se de uma série de casos, com delineamento longitudinal. População e amostra composta por todos os prontuários de RNPTMBP com menos de 36 semanas de idade gestacional e peso menor que 1.500g que responderam aos seguintes critérios de inclusão: clinicamente estáveis, de qualquer sexo, em uso de qualquer tipo de sonda pelo qual receberam leite humano pasteurizado e/ou que receberam leite humano pasteurizado com aditivo de fortificante comercial FM85®, e, que não apresentavam patologias que pudessem interferir no crescimento e ganho de peso. A partir do levantamento, constituiu-se dois grupos: recém-nascidos pré-termo de muito baixo peso que receberam leite humano pasteurizado (Grupo A) e os que receberam leite humano pasteurizado acrescido de FM85® (Grupo B). Resultados verificou-se que não houve diferença estatisticamente significativa entre os recém-nascidos pré-termo de muito baixo peso avaliados na comparação entre os dois grupos e entre o grupo analisado em dois momentos com as diferentes dietas. Observou-se, que a idade gestacional influenciou no ganho de peso diário em ambas as comparações. Conclusão Concluiu-se que as duas dietas utilizadas não implicaram em diferença estatisticamente significativas no crescimento quando comparados os dois grupos.

Resumen Objetivo comparar el crecimiento de recién nacidos prematuros de muy bajo peso internados en la Unidad de Terapia Intensiva Neonatal, alimentados con LHP y LHP con suplemento comercial. Métodos se trata de una serie de casos, con delineamiento longitudinal. Población y muestra compuesta por todas las historias clínicas de los RNPT MBP con menos de 36 semanas de edad gestacional y peso menor a 1.500 g que respondían los siguientes criterios de inclusión: clínicamente estable, de cualquier sexo, en uso de cualquier tipo de sonda por la cual recibe leche humana pasteurizada o leche humana pasteurizada con suplemento fortificador comercial FM85® y que no presente patologías que puedan interferir en el crecimiento y aumento de peso. A partir del análisis, se formaron dos grupos: recién nacidos pretérmino de muy bajo peso que recibieron leche humana pasteurizada (Grupo A) y los que recibieron leche humana pasteurizada suplementada con FM85® (Grupo B). Resultados se comprobó que no hubo diferencias estadísticamente significativas entre los recién nacidos pretérmino de muy bajo peso analizados respecto a la comparación entre los dos grupos y entre el grupo analizado en dos momentos con las diferentes dietas. Se observó que la edad gestacional influyó en el aumento de peso diario en ambas comparaciones. Conclusión se concluyó que las dos dietas utilizadas no implicaron diferencias estadísticamente significativas en el crecimiento cuando se compararon los dos grupos.

Abstract Objective To compare the growth of very low birth weight preterm infants admitted to the neonatal intensive care unit, fed with pasteurized human milk and pasteurized human milk plus a commercial supplement. Methods This was a series of cases, with a longitudinal design. Population and sample were comprised of all the records of infants less than 36 weeks gestational age, weighing less than 1,500 grams, who met the following inclusion criteria: clinically stable, of either sex, without diseases that could interfere in the growth and weight gain, using any type of tube through which they received pasteurized human milk and/or pasteurized human milk enhanced with FM85®, a commercial fortifying additive. Two groups were created: very low birth weight infants who received pasteurized human milk (Group A) and those who received pasteurized human milk enhanced with FM85® (Group B). Results No statistically significant difference was found between the two groups of very low preterm newborns, with the different diets evaluated at two different times. The gestational age influenced daily weight gain in both comparisons. Conclusion No statistically significant difference in growth was identified when comparing the two groups.

Bone age determination in eutrophic, overweight and obese Brazilian children and adolescents: a comparison between computerized BoneXpert and Greulich-Pyle methods.

BACKGROUND: Bone age determination is usually employed to evaluate growth disorders and their treatment. The Greulich-Pyle method is the simplest and most frequently used type of evaluation, but it presents huge interobserver variability. The BoneXpert is a computer-automated method developed to avoid significant bone age variability among distinct observers. OBJECTIVE: To compare the BoneXpert and Greulich-Pyle methods of bone age determination in eutrophic children and adolescents, as well as in overweight and obese pediatric patients. MATERIALS AND METHODS: The sample comprised 515 participants, 253 boys (159 eutrophic, 53 overweight and 41 obese) and 262 girls (146 eutrophic, 76 overweight and 40 obese). Left hand and wrist radiographs were acquired for bone age determination using both methods. RESULTS: There was a positive correlation between chronological age and Greulich-Pyle, chronological age and BoneXpert, and Greulich-Pyle and BoneXpert. There was a significant increase (P<0.05) in bone age in both the Greulich-Pyle and BoneXpert methods in obese boys when compared to eutrophic or overweight boys of the same age. In girls, there was an increase in bone age in both obese and overweight individuals when compared to eutrophic girls (P<0.05). The Greulich-Pyle bone age was advanced in comparison to that of BoneXpert in all groups, except in obese boys, in which bone age was similarly advanced in both methods. CONCLUSION: The BoneXpert computer-automated bone age determination method showed a significant positive correlation with chronological age and Greulich-Pyle. Furthermore, the impact of being overweight or obese on bone age could be identified by both methods.

Influence of surface treatments in flexural strength and superficial topography of a lithium disilicate ceramic / Influência dos tratamentos de superfície na resistência à flexão e na topografia superficial de uma cerâmica de dissilicato de lítio

Objective: The aim of the study was to evaluate the influence of different surface post-etching treatments in flexural strength, contact angle and surface roughness of a lithium disilicate ceramic. Material and Methods: 60 bars (16 x 2 x 4 mm) were divided in six groups (n=10): C, no treatment; HF, hydrofluoric acid for 20 s (HF) + washing (60 s), drying (30s); HFL, HF + washing (60 s), drying (30 s) and luting; HFNL, HF + washing (60 s) + neutralization with sodium bicarbonate (SB) for 40 s + washing (5s), drying (30 s) and luting; HFUL, HF + washing (60 s) + ultrasonic bath (UB) for 4 min, drying (30 s) and luting; HFNUL, HF + washing (60 s) + SB (40 s) + UB (4 min) and luting. The bars were submitted to three-points flexural strength test. 25 ceramic blocks (12 x 7 x 7 mm) were divided into five groups (n=5) to evaluate roughness and contact angle C - no treatment; HF - HF ; HFU - HF and UB for 5 min ; HFN - HF and SB; HFNU - HF, UB and SB. A scanning electron microscope (SEM) showed the surface of the samples. ANOVA one-way statistical analysis was done for comparison of results. Results: There was no statistical difference for flexural strength (p-value = 0.15) and for surface roughness (p-valor = 0.15). However, it was obtained statistically significant difference for contact angle (p-valor = 0.00). SEM images showed precipitates after the acid etching, which were removed by post-etching treatments. Conclusion: It can be concluded that the different post-etching surface treatments did not increase the flexural strength, surface roughness, but it influenced the ceramic wetting and SEM images (AU)

Objetivo: O objetivo do estudo foi avaliar a influência de diferentes tratamentos pós-condicionamento na resistência à flexão, ângulo de contato e rugosidade superficial de uma cerâmica de dissilicato de lítio. Material e Métodos: 60 barras (16 x 2 x 4 mm) foram divididas em seis grupos (n = 10): C, sem tratamento; HF, ácido fluorídrico durante 20 s (HF) + lavagem (60 s), secagem (30 s); HFL, lavagem com HF + (60 s), secagem (30 s) e cimentação; HFNL, HF + lavagem (60 s) + neutralização com bicarbonato de sódio (SB) por 40 s + lavagem (5s), secagem (30 s) e cimentação; HFUL, HF + lavagem (60 s) + banho ultrassônico (UB) por 4 min, secagem (30 s) e cimentação; HFNUL, HF + lavagem (60 s) + SB (40 s) + UB (4 min) e cimentação. As barras foram submetidas ao teste de resistência à flexão de três pontos. 25 blocos cerâmicos (12 x 7 x 7 mm) foram divididos em cinco grupos (n = 5) para avaliação da rugosidade superficial e ângulo de contato C - sem tratamento; HF - HF; HFU - HF e UB por 5 min; HFN - HF e SB; HFNU - HF, UB e SB. Um microscópio eletrônico de varredura (MEV) foi utilizado para análise da superfície das amostras. A análise estatística unidirecional ANOVA-um fator foi realizada para comparação dos resultados. Resultados: Não houve diferença estatística para a resistência à flexão (p-valor = 0,15) e para a rugosidade superficial (p-valor = 0,15). No entanto, obteve-se diferença estatisticamente significante para o ângulo de contato (p-valor = 0,00). Imagens de microscopia eletrônica de varredura mostraram a formação de precipitados após o ataque ácido, que foram removidos pelos tratamentos pós-condicionamento. Conclusão: Pode-se concluir que os diferentes tratamentos de superfície pós-condicionamento não aumentaram a resistência à flexão, rugosidade da superfície, mas influenciaram na molhabilidade da cerâmica e nas imagens em MEV.(AU)

Influence of indirect reinforcements on the flexural strength of a thermally activated acrylic resin used for complete dentures / Influência de reforços indiretos na resistência a flexão de uma resina acrílica ativada térmicamente utilizada na confecção de próteses totais

Objective: This research aimed to verify the performance of thermally activated acrylic resin (TAAR) combined with a mix of glass and aramid fibers and/or composite resin of indirect use by a tree point bending test. Material and Methods: Ten samples, with 65 x 10 x 2.5 mm, were prepared for each group (n = 10): CO, control of only TAAR; CR, in which an 60 mm indirect composite resin was polymerized together with the acrylic resin during the thermo-polymerization cycle; SS, in which ceramic glass mixed with aramid fibers cut 60 mm in length were incorporated into the samples; and SC, in which the same fibers were incorporated with addiction of the indirect composite resin. A three point flexural strength test was performed with a universal testing machine with a load of 50KgF at a speed of 5 mm/min in the center of the samples supported by a suitable device. The reinforced face was placed to the tensile side. The statistical one way ANOVA and Tukey tests were made with a significance level of 95%. Results: The mean value for the CO was 60,27 ± 24,18 MPa, for CR it was 38,39±12,75 MPa, for SS it was 79,97±12,75 Mpa and for CS it was 32,40±9,05 MPa. Conclusion: The use of glass and aramid fibers at the base of a TAAR increased the three-point flexural strength, however when indirect composite resin was incorporated, a significant drop of this mechanical property was observed. (AU)

Objetivo: Esta pesquisa teve como objetivo verificar o desempenho de uma resina acrílica ativada termicamente (RAAT) combinada com uma mistura de fibras de vidro e aramida e / ou resina composta de uso indireto por um teste de flexão de três pontos. Material e Métodos: Foram preparadas dez amostras, com 65 x 10 x 2,5 mm, para cada grupo (n = 10): CO, controle com apenas RAAT; CR, em que uma resina composta indireta de 60 mm com polimerizada em conjunto com a resina acrílica durante o ciclo de termopolimerização; SS, em que o vidro cerâmico misturado com fibras de aramida cortadas com 60 mm de comprimento foi incorporado nas amostras; e SC, nas quais as mesmas fibras foram incorporadas em conjunto com a resina composta indireta. O teste de resistência à flexão de três pontos foi realizado em uma máquina de teste universal com uma carga de 50 KgF a uma velocidade de 5 mm/min no centro das amostras suportadas por um dispositivo adequado. A face reforçado foi colocado no lado da tração. Os testes estatísticos one-way ANOVA e Tukey foram feitos com um nível de significância de 95%. Resultados: O valor para o CO foi de 60,27 ± 24,18 MPa, para CR foi de 38,39 ± 12,75 MPa, para SS foi de 79,97 ± 12,75 Mpa e para CS foi de 32, 40 ± 9,05 MPa. Conclusão: o uso de fibras de vidro e aramida na base de uma RAAT aumentou a resistência à flexão de três pontos, no entanto, quando a resina composta indireta foi incorporada, observou-se uma queda significativa dessa propriedade mecânica (AU)

Influence of post-etching surface treatment and thermo-mechanical cycling on fracture strength of ceramics.

BACKGROUNG: The aim of this study was to evaluate fracture strength of lithium disilicate-based ceramic crowns submitted to neutralization of hydrofluoric acid (HF) precipitates associated with ultrasonic bath and to thermo-mechanical cycling. METHODS: Eighty human molars received conventional full crown preparation after being included in polyurethane standard to simulate periodontal ligament. After scanning, the ceramic blocks were machined using CAD/CAM system to obtain the crowns. The crowns were distributed according to surface treatment: S and S-C; HF and silane; SNU and SNU-C; HF neutralization of HF precipitates, ultrasonic bath and silane. The crowns were cemented with dual cure resin cement and the specimens in Groups S-C and SNU-C were submitted to thermo-mechanical cycling (5/55 °C/60 s while 1.2 million mechanical cycles of 4 Hz/100 N). The samples were submitted to compressive test. Analysis of fractures was performed macroscopically (Burke method) and using Scanning Electron Microscope. The data of fracture strength were analyzed using the two-way ANOVA. RESULTS: No statistical difference among the groups was found (p-value = 0,799). Most failures were associated with the remaining tooth fracture and the fracture origin was located on the cementation surface. CONCLUSIONS: Postetching cleaning protocols do not improve the fracture strength of ceramics crowns. Thermo-mechanical aging did not weakened the ceramic crown.

Electromyographic activity in patient with an inferior implant/tooth-supported overdenture: clinical report / Atividade eletromiográfica de um paciente com prótese inferior implantodentossuportada: Relato de caso clínico

Clinicians can find patients with one mandibular remaining tooth, and it is difficult to decide if the tooth has to be removed. When a clinician decides to maintain the tooth, it is common to question the masticatory load distribution divided between the tooth and implant. This paper reports a clinical case of patient with an implant/tooth-supported overdenture and elucidates the masticatory efficiency by electromyography activity analysis. The objective of this case report was to describe a clinical case of a patient with an implant/tooth-supported overdenture and to discuss the muscle response to this treatment. Electrical activities of the masseter and anterior temporal surfaces at maximum voluntary contraction were evaluated by electromyography during pre-treatment, immediately post-treatment,15 and 60 days after installation. When patienthas one remaining tooth in good condition, theimplant/tooth-supported overdenture can be recommended, to preserve the periodontal ligament and proprioception, and to minimize bone loss. Electromyography analysis showed that implant/tooth-supported overdenture is a viable treatment alternative, in muscular stand point, when the patient has a remaining tooth with good osseous support...

Os dentistas podem encontrar casos em que o paciente possui apenas um dente mandibular remanescente,sendo difícil decidir se o dente deverá ser extraído. Quando o clínico decide manter este dente, é comum surgirem dúvidas sobre como ocorre a distribuição da carga mastigatória em próteses suportadas por dente e implante. Este artigo relata a resposta muscular por meio de atividade eletromiográfica de um paciente reabilitado com uma prótese inferior implantodentossuportada. O objetivo deste artigo foi descrever este caso clínico e discutir a resposta musculatória neste tipo de tratamento. As atividades eletromiográficas dos músculos massetere temporal anterior superficial foram avaliadas durante o pré-tratamento, imediatamente após a instalação da prótese, 15 e 60 dias pós-tratamento.Foi verificado que quando o paciente tem um dente remanescente em condição de ser mantido, a prótese implantodentossuportada pode ser recomendada como tratamento, para preservação do ligamento periodontal e da propriocepção, e para minimizar a perda óssea. A análise eletromiográfica demonstrou que a prótese implantodentossuportada é uma alternativa viável de tratamento, do ponto de vista muscular, quando o paciente possui um dente remanescente com suporte ósseo adequado...

How do primary health care professionals deal with pregnant women who are victims of domestic violence?

OBJECTIVES: to determine how Family Health Strategy professionals recognize and deal with domestic violence in pregnant women. METHOD: qualitative study based on the Theory of Praxis Intervention in Collective Health Nursing (TIPESC). Fourteen professionals at a Basic Health Unit in the east side of Sao Paulo/Brazil were interviewed. Empirical data were categorized and discussed in thematic groups. For data analysis was used the technique of Discourse Analysis. RESULTS: we identified low number of reported cases of domestic violence; lack of education and training of health care professionals; failure in the identification and intervention process due to bias on their personal problems, moral attitudes and prejudice against these women. In addition, the study showed that their labor process was based entirely on the biological aspects of the women and to overcome this, they need of proper rapport between health care professionals and pregnant women to deal with of domestic violence. CONCLUSION: professionals should develop skills to intervene in violence against pregnant women and also modify labor processes considering women in their totality and part of society.

How do primary health care professionals deal with pregnant women who are victims of domestic violence? / Como os profissionais da Atenção Básica enfrentam a violência na gravidez? / ¿Cómo los profesionales de la atención primaria enfrentan la violencia contra las mujeres embarazadas?

OBJECTIVES: to determine how Family Health Strategy professionals recognize and deal with domestic violence in pregnant women. METHOD: qualitative study based on the Theory of Praxis Intervention in Collective Health Nursing (TIPESC). Fourteen professionals at a Basic Health Unit in the east side of Sao Paulo/Brazil were interviewed. Empirical data were categorized and discussed in thematic groups. For data analysis was used the technique of Discourse Analysis. RESULTS: we identified low number of reported cases of domestic violence; lack of education and training of health care professionals; failure in the identification and intervention process due to bias on their personal problems, moral attitudes and prejudice against these women. In addition, the study showed that their labor process was based entirely on the biological aspects of the women and to overcome this, they need of proper rapport between health care professionals and pregnant women to deal with of domestic violence. CONCLUSION: professionals should develop skills to intervene in violence against pregnant women and also modify labor processes considering women in their totality and part of society. .

OBJETIVO: conhecer como os profissionais da Estratégia de Saúde da Família reconhecem e enfrentam o fenômeno da violência doméstica contra as mulheres grávidas. MÉTODO: estudo de abordagem qualitativa, ancorado na Teoria de Intervenção Práxica da Enfermagem em Saúde Coletiva. Foram entrevistados 14 profissionais de uma Unidade Básica de Saúde da zona leste de São Paulo, Brasil. Os dados empíricos foram analisados em grupos temáticos e discutidos com base na literatura e referencial adotado pelo estudo. RESULTADOS: a análise dos discursos identificou: invisibilidade da violência doméstica diante do baixo número de notificações de casos; falta de formação e capacitação dos profissionais de saúde com relação ao fenômeno; dificuldades desses profissionais no processo de identificação e intervenção devido a questões pessoais, a posturas preconceituosas e moralistas e ao método de trabalho pautado nos aspectos biológicos e, por fim, a análise identificou a importância do vínculo entre os profissionais da saúde e a mulher grávida no processo de identificação e intervenção da violência doméstica. CONCLUSÃO: há imediata necessidade de se desenvolver as competências dos profissionais e modificar os processos de trabalho para o enfrentamento da violência doméstica, prioritariamente nas adolescentes grávidas vítimas de violência. .

OBJETIVOS: conocer cómo los profesionales de la Estrategia de Salud de la Familia reconocen y enfrentan el fenómeno de la violencia doméstica contra las mujeres embarazadas. MÉTODO: estudio de abordaje cualitativo basado en la Teoría de Intervención Práxica de la Enfermería en Salud Colectiva (TIPESC). Se entrevistó a catorce profesionales de una Unidad Básica de Salud en la zona este de Sao Paulo - Brasil. En este estudio se utilizó la técnica de Análisis del Discurso. Los datos empíricos fueron categorizados en grupos temáticos y discutidos en base a la literatura y el marco teórico adoptado por el estudio. RESULTADOS: el análisis de las declaraciones identificó la invisibilidad de la violencia doméstica en base al bajo número de casos notificados, la falta de formación y capacitación de los profesionales de la salud sobre el fenómeno, las dificultades de estos profesionales en el proceso de identificación e intervención basado en los problemas personales, por prejuicios, por actitudes moralistas; y por el método de trabajo basándose en sólo los aspectos biológicos y, la importancia del vínculo entre profesionales de la salud y la mujer embarazada en el proceso de identificación e intervención de la violencia doméstica. CONCLUSIÓN: existe necesidad inmediata para el desarrollo de las competencias de los profesionales y modificación de los procesos de trabajo para hacer frente a la violencia doméstica como una prioridad en embarazadas adolescentes víctimas de esta violencia. .

Effect of the layering technique on bond strength and cohesive resistance of a porcelain-zirconia system.

PURPOSE: To evaluate the influence of the number of porcelain layers on its cohesive strength and on bonding to zirconia. MATERIALS AND METHODS: Y-TZP blocks were cut into 1 cm3 specimens (n = 30). The feldspathic porcelain (V9) was applied to the zirconia in different numbers of layers up to 1 cm total thickness (n = 10): ZP1 - one layer; ZP2 - two layers; ZP3 - three layers. Ten specimens with V9 were prepared following the same protocols of groups 1 (P1) and 3 (P3). All study specimens were sintered three times. The specimens were cut into 1 mm2 microbars and tested under tension in a universal testing machine (0.5 mm/min). We calculated strength (σ, in MPa) by dividing the fracture load (N) by the fractured area (mm2). The failure mode was classified as cohesive (used to calculate the cohesive strength, σc) or adhesive (bond strength, σa). The data were analyzed by Kruskal-Wallis and Dunn's tests (α = 0.05) or ANOVA and Tukey's test (α = 0.05), according to their distribution parameters. RESULTS: The ZP1 group presented the highest values for σa data, compared with other groups, which were statistically similar. The predominant failure mode for the bonded specimens was cohesive. With regard to the cohesive strength (σc), ZP1 presented the highest values. CONCLUSION: It can be concluded that the presence of more than one porcelain layer decreases its cohesive strength and its bonding strength to zirconia.

May the flexural strength of ceramics be influenced by salivary pH? / A resistência à flexão de cerâmicas pode ser influenciada pelo pH salivar?

Objective: This study purpose was to compare the three-point flexural strength of feldspathic ceramic after storage in artificial saliva for 30 days with different pH regimens, as acidic pH (3.5), neutral pH (7.0), basic pH (10) and alternating between acid/ basic pH, for 15 days each. Material and Methods: The bars were luted with resin cement and subjected to storage in artificial saliva of different pH values. Results: The values of flexural strength were significantly higher for bars stored in distilled water, at neutral and basic pH, when compared with the results for bars stored in acidic pH and in acid/basic pH. Conclusions: Storage for 30 days in artificial saliva at acidic pH, or alternating between acidic and basic pH, can reduce the mechanical properties of ceramics.

Objetivo: O objetivo do estudo foi comparar a resistência à flexão três pontos de uma cerâmica feldspática após armazenagem em saliva artificial, durante 30 dias com diferentes regimes de pH: pH ácido (3,5), pH neutro (7,0), pH básico (10) e alternando entre pH ácido/básico durante 15 dias cada. Material e Métodos: As barras foram cimentados com cimento resinoso e submetidas a armazenagem em saliva artificial com os diferentes valores de pH. Resultados: Os valores de resistência à flexão foram significativamente maiores para as barras armazenadas em água destilada, em pH neutro e em básico, quando comparadas com os resultados para as barras armazenadas em pH ácido e em meio ácido/básico. Conclusões: A armazenamento durante 30 dias em saliva artificial, com pH ácido, ou alternando entre pH ácido e basico, pode reduzir as propriedades mecânicas das cerâmicas

Efeito de diferentes tempos de condicionamento e condições de envelhecimento na resistência à flexão de cerâmicas ácido sensíveis / Effect of different times of conditioning and storage conditions on the flexural strength of acid-sensitive ceramics

As cerâmicas são indicadas para coroas livres de metal, pois alcançaram resistência suficiente para resistir às cargas funcionais. O objetivo neste estudo foi avaliar a resistência à flexão de barras cerâmicas, após diferentes tempos de condicionamento com ácido fluorídrico, e diferentes protocolos de envelhecimento. Foram confeccionadas 500 barras cerâmicas com dimensões de 16 mm x 4 mm x 2 mm, sendo 250 para cada tipo de cerâmica. As barras foram lixadas e polidas e distribuídas em 5 grandes grupos com 50 amostras cada e foram condicionadas com ácido fluorídrico a 10%, variando os tempos de condicionamento entre 20, 30, 40, 60 e 90 segundos. Posteriormente, foi aplicado o agente silano e uma camada fina de cimento resinoso dual. Foram então subdivididas em 5 diferentes meios de envelhecimento: termociclagem, ciclagem mecânica, ciclagem termomecânica, ciclagem intra-bucal e controle. Após os ciclos, as amostras foram submetidas ao teste de resistência à flexão, em uma máquina de ensaio universal EMIC, com velocidade de 1mm/min. Os valores médios forma submetidos a análise estatística ANOVA 2 fatores e comparação de Tukey 5%. Para a cerâmica feldspática tanto o grupo controle quanto o grupo submetido à ciclagem termomecânica apresentaram valores mais homogêneos em relação ao tempo de condicionamento. No grupo submetido à ciclagem mecânica, houve um aumento da resistência quando condicionado por 90 segundos. No grupo ciclado termicamente houve uma queda nos valores de resistência quando condicionados por 40 segundos, e no grupo intra-bucal, uma queda quando condicionados por 60 segundos. Uma expressiva diferença foi encontrada entre os grupos condicionados por 40 e 60 segundos, ambos submetidos à ciclagem intra-bucal. Para a cerâmica de dissilicato de lítio o maior valor de resistência à flexão foi obtido no grupo controle, condicionado por 90 segundos. Os menores valores de resistência à flexão foram encontrado nos grupos submetidos...

Ceramics can be indicated for metal free crowns, since they have reached sufficient strength to withstand functional loads. The objective of this study was to evaluate the flexural strength of feldspathic bars and lithium disilicate, after different times of etching with hydrofluoric acid, and different protocols of aging. Five hundred bars (16 mm x 4 mm x 2 mm) were prepared, 250 for each type of ceramic. The bars were grounded, polished and distributed in 5 groups of 50 samples each and were etched with 10% hydrofluoric acid, varying the conditioning time (20, 30, 40, 60 and 90 seconds). Subsequently, the silane agent was applied followed by a thin layer of dual resin cement. Samples were then divided into five different ways of aging: thermal cycling, mechanical cycling, thermomechanical cycling, intra-oral cycling and control. After the cycles, the samples were subjected to flexural strength testing in a universal testing machine (EMIC), at a speed of 1 mm / min. Mean values were submitted to two-way ANOVA and Tukey test (á =5%). Both feldspathic ceramic control group and the group submitted to thermomechanical cycling showed more homogeneity regarding the conditioning time. In the group submitted to mechanical loading, there was an increase in the resistance when conditioning for 90 seconds. The thermally cycled group presented decrease in the strength values when conditioned for 40 seconds, and the intra-oral group, a decrease when conditioned for 60 seconds. The most significant difference was found between the groups conditioned for 40 and 60 seconds, both when submitted to intra-oral cycling. For lithium disilicate ceramic, the highest value of flexural strength was obtained in the control group, conditioned for 90 seconds. The lower values of flexural strength were found in groups submitted to intra-oral cycling, conditioned by 30 and 40 seconds....(AU)

Efeito de diferentes tempos de condicionamento e condições de envelhecimento na resistência à flexão de cerâmicas ácido sensíveis / Effect of different times of conditioning and storage conditions on the flexural strength of acid-sensitive ceramics

As cerâmicas são indicadas para coroas livres de metal, pois alcançaram resistência suficiente para resistir às cargas funcionais. O objetivo neste estudo foi avaliar a resistência à flexão de barras cerâmicas, após diferentes tempos de condicionamento com ácido fluorídrico, e diferentes protocolos de envelhecimento. Foram confeccionadas 500 barras cerâmicas com dimensões de 16 mm x 4 mm x 2 mm, sendo 250 para cada tipo de cerâmica. As barras foram lixadas e polidas e distribuídas em 5 grandes grupos com 50 amostras cada e foram condicionadas com ácido fluorídrico a 10%, variando os tempos de condicionamento entre 20, 30, 40, 60 e 90 segundos. Posteriormente, foi aplicado o agente silano e uma camada fina de cimento resinoso dual. Foram então subdivididas em 5 diferentes meios de envelhecimento: termociclagem, ciclagem mecânica, ciclagem termomecânica, ciclagem intra-bucal e controle. Após os ciclos, as amostras foram submetidas ao teste de resistência à flexão, em uma máquina de ensaio universal EMIC, com velocidade de 1mm/min. Os valores médios forma submetidos a análise estatística ANOVA 2 fatores e comparação de Tukey 5%. Para a cerâmica feldspática tanto o grupo controle quanto o grupo submetido à ciclagem termomecânica apresentaram valores mais homogêneos em relação ao tempo de condicionamento. No grupo submetido à ciclagem mecânica, houve um aumento da resistência quando condicionado por 90 segundos. No grupo ciclado termicamente houve uma queda nos valores de resistência quando condicionados por 40 segundos, e no grupo intra-bucal, uma queda quando condicionados por 60 segundos. Uma expressiva diferença foi encontrada entre os grupos condicionados por 40 e 60 segundos, ambos submetidos à ciclagem intra-bucal. Para a cerâmica de dissilicato de lítio o maior valor de resistência à flexão foi obtido no grupo controle, condicionado por 90 segundos. Os menores valores de resistência à flexão foram encontrado nos grupos submetidos...

Ceramics can be indicated for metal free crowns, since they have reached sufficient strength to withstand functional loads. The objective of this study was to evaluate the flexural strength of feldspathic bars and lithium disilicate, after different times of etching with hydrofluoric acid, and different protocols of aging. Five hundred bars (16 mm x 4 mm x 2 mm) were prepared, 250 for each type of ceramic. The bars were grounded, polished and distributed in 5 groups of 50 samples each and were etched with 10% hydrofluoric acid, varying the conditioning time (20, 30, 40, 60 and 90 seconds). Subsequently, the silane agent was applied followed by a thin layer of dual resin cement. Samples were then divided into five different ways of aging: thermal cycling, mechanical cycling, thermomechanical cycling, intra-oral cycling and control. After the cycles, the samples were subjected to flexural strength testing in a universal testing machine (EMIC), at a speed of 1 mm / min. Mean values were submitted to two-way ANOVA and Tukey test (á =5%). Both feldspathic ceramic control group and the group submitted to thermomechanical cycling showed more homogeneity regarding the conditioning time. In the group submitted to mechanical loading, there was an increase in the resistance when conditioning for 90 seconds. The thermally cycled group presented decrease in the strength values when conditioned for 40 seconds, and the intra-oral group, a decrease when conditioned for 60 seconds. The most significant difference was found between the groups conditioned for 40 and 60 seconds, both when submitted to intra-oral cycling. For lithium disilicate ceramic, the highest value of flexural strength was obtained in the control group, conditioned for 90 seconds. The lower values of flexural strength were found in groups submitted to intra-oral cycling, conditioned by 30 and 40 seconds...

Fracture resistance of composite resin cores with or without prefabricated posts over different substrates.

The fracture resistance of endodontically treated teeth has been an obstacle to the durability of the remaining teeth and restorations. The aim of this study was to evaluate the fracture resistance of endodontically treated bovine and human teeth that were restored with either prefabricated metal posts, glass fiber posts, or composite resin cores. Statistical analysis revealed significant difference between different substrates, but there was no statistically significant difference between different types of intraradicular posts or in the interaction between substrate and post types. The intraradicular posts do not increase the fracture resistance of endodontically treated teeth. The metal posts presented more unfavorable fracture modes when compared to glass fiber posts and composite resin cores.

Effect of cement type, relining procedure, and length of cementation on pull-out bond strength of fiber posts.

INTRODUCTION: As opposed to the cementation metal posts, the cementation of fiber posts has several details that can significantly influence the success of post retention. This study evaluated the effect of the relining procedure, the cement type, and the luted length of the post on fiber posts retention. METHODS: One hundred eighty bovine incisors were selected to assess post retention; after endodontic treatment, the canals were flared with diamonds burs. Post holes were prepared in lengths of 5, 7.5, and 10 mm; the fiber posts were relined with composite resin and luted with RelyX ARC, RelyX Unicem, or RelyX Luting 2. All cements are manufactured by 3M ESPE (St. Paul, MN). Samples were subjected to a pull-out bond strength test in a universal testing machine; the results (N) were submitted to a three-way analysis of variance and the Tukey post hoc test (alpha = 0.05). RESULTS: The improvement of post retention occurred with the increase of the post length luted into the root canal; the relining procedure improved the pull-out bond strength. RelyX Unicem and RelyX ARC showed similar values of retention, both showing higher values than RelyX Luting 2. CONCLUSION: Post length, the relining procedure, and the cement type are all important factors for improving the retention of fiber posts.